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Phenotypes Associated with This Genotype
Genotype
MGI:5519120
Allelic
Composition
Del(16Dgcr2-Hira)3Aam/+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants require more training in the T-maze task than controls to reach criterion, indicating a learning impairment

nervous system
• hippocampal-prefrontal synchrony is reduced during working memory performance on the discrete-trial T-maze task
• phase-locking of prefrontal neurons to hippocampal theta oscillations and coherence of prefrontal and hippocampal local field potentials are reduced
• coherence is lower in mutants before training when tested on center-arm runs during habituation, indicating that hippocampal-prefrontal circuit synchrony is impaired at baseline

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500
J:158957


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2018
MGI 6.11
The Jackson Laboratory