Mouse Genome Informatics
ht
    Del(16Dgcr2-Hira)3Aam/+
involves: 129S7/SvEvBrd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• mutants require more training in the T-maze task than controls to reach criterion, indicating a learning impairment

nervous system
• hippocampal-prefrontal synchrony is reduced during working memory performance on the discrete-trial T-maze task
• phase-locking of prefrontal neurons to hippocampal theta oscillations and coherence of prefrontal and hippocampal local field potentials are reduced
• coherence is lower in mutants before training when tested on center-arm runs during habituation, indicating that hippocampal-prefrontal circuit synchrony is impaired at baseline

Mouse Models of Human Disease
OMIM IDRef(s)
Schizophrenia; SCZD 181500 J:158957