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Phenotypes Associated with This Genotype
Genotype
MGI:5517439
Allelic
Composition
Tg(CTSG-RARA/ZBTB16)#Sjch/0
Tg(CTSG-ZBTB16/RARA)#Sjch/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• impairment of normal hematopoiesis

tumorigenesis
• mutants develop myeloid leukemia resembling human t(11;17) acute promyelocytic leukemia, showing an accumulation of immature myeloblastic cells in hematopoietic tissues and infiltration of nonhematopoietic organs, including the liver, lung, gastrointestinal tract, and kidney

Mouse Models of Human Disease
OMIM ID Ref(s)
Acute Promyelocytic Leukemia; APL 612376 J:194312


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory