Phenotypes Associated with This Genotype

Genotype
MGI:5517402

• Allelic Composition: Tg(CTSG-ZBTB16/RARA)#Sjch/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased leukemia incidence ( J:55196 )

• 6 of 51 founders develop leukemia, usually with short latent periods of 31-85 days after birth

increased chronic myelocytic leukemia incidence ( J:55196 )

• develop chronic myeloid leukemia-like phenotypes within 3 months of life

• mutants with leukemia show an increased percentage of mature myeloid cells and myeloid/lymphoid ratio in the peripheral blood and bone marrow resembling chronic myeloid leukemia

growth/size/body

decreased body weight ( J:55196 )

• mutants with leukemia have low body weight

enlarged spleen ( J:55196 )

• mutants with leukemia exhibit splenomegaly

hematopoietic system

abnormal myelopoiesis ( J:55196 )

• about 20% increase in promyelocytes

• extreme expansion of myeloid cells at varying stages of maturation

myeloid hyperplasia ( J:55196 )

• extreme expansion of myeloid cells at varying stages of maturation

increased leukocyte cell number ( J:55196 )

abnormal spleen morphology ( J:55196 )

• follicular architecture is damaged

enlarged spleen ( J:55196 )

• mutants with leukemia exhibit splenomegaly

abnormal spleen red pulp morphology ( J:55196 )

• red pulp is infiltrated by myeloid cells, mainly myelocytes, metamyelocytes, and segmented forms

abnormal bone marrow cell physiology ( J:55196 )

• all-trans-retinoic acid treatment does not induce bone marrow cells to differentiate as in controls

immune system

abnormal myelopoiesis ( J:55196 )

• about 20% increase in promyelocytes

• extreme expansion of myeloid cells at varying stages of maturation

myeloid hyperplasia ( J:55196 )

• extreme expansion of myeloid cells at varying stages of maturation

increased leukocyte cell number ( J:55196 )

abnormal spleen morphology ( J:55196 )

• follicular architecture is damaged

enlarged spleen ( J:55196 )

• mutants with leukemia exhibit splenomegaly

abnormal spleen red pulp morphology ( J:55196 )

• red pulp is infiltrated by myeloid cells, mainly myelocytes, metamyelocytes, and segmented forms

liver/biliary system

abnormal liver morphology ( J:55196 )

• focal infiltration of liver with myeloid precursors, however gross structure of the liver is unaffected

skeleton

abnormal bone marrow morphology ( J:55196 )

• disruption of bone marrow trabeculae