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Phenotypes Associated with This Genotype
Genotype
MGI:5515733
Allelic
Composition		 Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv/?
Tg(Fabp4-cre/ERT2)1Ipc/0
Tyk2tm1Shmd/Tyk2tm1Shmd
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Fabp4-cre/ERT2)1Ipc mutation (0 available)
Tyk2tm1Shmd mutation (0 available); any Tyk2 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
adipose tissue phenotype ( J:195099 )
N
• mice exhibit normal brown adipose tissue morphology with reduced body weight compared to single Tyk2 homozygotes

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:195099 )
N
• mice exhibit improved insulin sensitivity compared to single Tyk2 homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory