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Phenotypes Associated with This Genotype
Genotype
MGI:5514344
Allelic
Composition
Tg(CTSG-ZBTB16/RARA)#Ppp/0
Zbtb16tm1Ppp/Zbtb16tm1Ppp
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CTSG-ZBTB16/RARA)#Ppp mutation (0 available)
Zbtb16tm1Ppp mutation (0 available); any Zbtb16 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• develop leukemia after 6 months of age characterized by an accumulation of blast/promyelocytic cells in the bone marrow and spleen in the absence of leukocytosis resembling acute promyelocytic leukemia
• leukemia is also characterized by infiltrating cells that are c-Kit, Gr-1, Mac-1 positive and display promyelocytic features

Mouse Models of Human Disease
OMIM ID Ref(s)
Acute Promyelocytic Leukemia; APL 612376 J:65878


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory