Mouse Genome Informatics
tg
    Tg(Prnp-MAPT*P301S)PS19Vle/0
B6.Cg-Tg(Prnp-MAPT*P301S)PS19Vle
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• in the Y-maze test, the total percentage of alternations is decreased indicating impaired spontaneous alternation (J:174441)
• in the Barnes circular maze test, males are able to locate the correct target hole where the escape box had been in the probe trial, however they spend less time around the target hole than wild-type mice (J:174441)
• in a portion of the Porsolt forced swim test, mutants show decreased immobility time and increased distance traveled, suggesting that despair-like behavior might be decreased, however, generally over the entire test, no statistical significance is seen for immobility (J:174441)
• in the elevated plus-maze test, entries into and time spent on the open arms is increased and in the open field test, time spent in the center of the field is increased, indicating decreased anxiety-like behavior (J:174441)
• in the contextual fear conditioning test, mutants show decreased immobility in the fourth time point only (J:174441)
• in the open field test, 14 week old males show an increase in total locomotive distance and an increase in stereotypic locomotion (J:174441)
• in the Y-maze test, males show increased numbers of entries into each arm, total alternations, and total distance traveled indicating hyperactivity (J:174441)
• vertical activity of 14 week old males is increased in the latter half of the open field test (J:174441)
• males exhibit decreased thresholds in the hot plate test, indicating increased antinociceptive responses (J:174441)
• in Crawley's three-chamber social approach test, males spend a shorter time with stranger mice than with familiar mice compared to wild-type mice which spend more time with stranger mice, indicating some impaired sociability or object recognition memory (J:174441)
• however, no differences were seen in the social interaction test of a one-chamber novel environment (J:174441)

integument
• males exhibit decreased thresholds in the hot plate test, indicating increased antinociceptive responses (J:174441)

nervous system
• hyperphosphorylated tau protein accumulation is seen in the lateral globus pallidus, amygdala, auditory cortex, ventral hippocampus, the cingulate cortex, anterior cortical amygdaloid nucleus, and dorsal hippocampus at 4 months of age (J:174441)
• males younger than 6 months of age exhibit lower startle amplitudes than wild-type mice at 110 dB and 120 dB and an increase in percent prepulse inhibition (J:174441)

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:174441