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Phenotypes Associated with This Genotype
Genotype
MGI:5510989
Allelic
Composition		 Tg(ACTB-Eif4e)#Ppp/0
Tg(IghMyc)22Bri/0
Genetic
Background		 involves: C57BL * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTB-Eif4e)#Ppp mutation (0 available)
Tg(IghMyc)22Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lymphoma incidence ( J:89878 )
• onset of lymphoma is accelerated compared to single Tg(IghMyc)22Bri transgenic mice and is evident at less than 1 month of age

cellular
decreased B cell apoptosis ( J:89878 )
• reduction in apoptosis of splenic B cells at 3 weeks of age, before lymphoma occurrence, compared to single Tg(IghMyc)22Bri transgenic mice

immune system
decreased B cell apoptosis ( J:89878 )
• reduction in apoptosis of splenic B cells at 3 weeks of age, before lymphoma occurrence, compared to single Tg(IghMyc)22Bri transgenic mice

hematopoietic system
decreased B cell apoptosis ( J:89878 )
• reduction in apoptosis of splenic B cells at 3 weeks of age, before lymphoma occurrence, compared to single Tg(IghMyc)22Bri transgenic mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory