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Phenotypes Associated with This Genotype
Genotype
MGI:5509206
Allelic
Composition
Tg(HBx)3Yu/0
Genetic
Background
involves: C57BL/6 * DBA
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phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mutants develop hepatocellular carcinoma, with small neoplastic nodules seen by 6 months of age and 64% of mutants showing hepatocellular carcinoma at 11-18 months of age
• overall incidence of hepatic tumors, including grossly identified hepatocellular carcinomas and small neoplastic nodules is 86% from 11-18 months of age

liver/biliary system
• non-neoplastic area of livers show small vacuoles in the cytoplasm and evidence of dysplasia, with mild to moderate pleomorphic nuclei and an increase in nuclear size with clumped chromatin
• mutants develop hepatocellular carcinoma, with small neoplastic nodules seen by 6 months of age and 64% of mutants showing hepatocellular carcinoma at 11-18 months of age
• overall incidence of hepatic tumors, including grossly identified hepatocellular carcinomas and small neoplastic nodules is 86% from 11-18 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:56196


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory