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Phenotypes Associated with This Genotype
Genotype
MGI:5508896
Allelic
Composition
Ins2Akita/Ins2Akita
Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic
Background
C.Cg-Ins2Akita Itga1tm1Gdnr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins2Akita mutation (13 available); any Ins2 mutation (25 available)
Itga1tm1Gdnr mutation (0 available); any Itga1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 40% of mutants fail to thrive and have to be euthanized before 6 months of age (J:198186)
• about 40% of mutants fail to thrive and have to be euthanized before 6 months of age (J:198186)

cardiovascular system
• mice show a a greater decrease in CD31 positive structures in the glomeruli than in single Ins2Akita homozygotes, indicating collapse of the glomerular tufts (J:198186)
• mice show a a greater decrease in CD31 positive structures in the glomeruli than in single Ins2Akita homozygotes, indicating collapse of the glomerular tufts (J:198186)

growth/size/body
• decreased body weight at 4 and 6 months of age compared to wild-type mice or single Itgal1tm1Gdnr homozygotes (J:198186)
• decreased body weight at 4 and 6 months of age compared to wild-type mice or single Itgal1tm1Gdnr homozygotes (J:198186)

homeostasis/metabolism
• develop a similar level of hyperglycemia as in single Ins2Akita homozygotes (J:198186)
• develop a similar level of hyperglycemia as in single Ins2Akita homozygotes (J:198186)
• 16-fold increase in albumin-to-creatine ratio at 4 months of age (J:198186)
• 16-fold increase in albumin-to-creatine ratio at 4 months of age (J:198186)

renal/urinary system
• 16-fold increase in albumin-to-creatine ratio at 4 months of age (J:198186)
• 16-fold increase in albumin-to-creatine ratio at 4 months of age (J:198186)
• glomerular basement membrane thickening is more severe than in single Ins2Akita homozygotes (J:198186)
• glomerular basement membrane thickening is more severe than in single Ins2Akita homozygotes (J:198186)
• increase in glomerular collagen IV deposition at 6 months of age is more abundant than in single Ins2Akita homozygotes (J:198186)
• increase in glomerular collagen IV deposition at 6 months of age is more abundant than in single Ins2Akita homozygotes (J:198186)
• mice show a a greater decrease in CD31 positive structures in the glomeruli than in single Ins2Akita homozygotes, indicating collapse of the glomerular tufts (J:198186)
• mice show a a greater decrease in CD31 positive structures in the glomeruli than in single Ins2Akita homozygotes, indicating collapse of the glomerular tufts (J:198186)
• excessive fibrillar collagen deposition in diffuse and nodular mesangial lesions (J:198186)
• excessive fibrillar collagen deposition in diffuse and nodular mesangial lesions (J:198186)
• increase in mesangial matrix expansion at 4 and 6 months of age is greater than in single Ins2Akita homozygotes (J:198186)
• diffuse and nodular mesangial sclerosis (J:198186)
• increase in mesangial matrix expansion at 4 and 6 months of age is greater than in single Ins2Akita homozygotes (J:198186)
• diffuse and nodular mesangial sclerosis (J:198186)
• severe (J:198186)
• severe (J:198186)
• small increase in collagen I in the tubulointerstitial compartment of the kidney (J:198186)
• however tubulointerstitial fibrosis is not observed (J:198186)
• small increase in collagen I in the tubulointerstitial compartment of the kidney (J:198186)
• however tubulointerstitial fibrosis is not observed (J:198186)
• glomerular filtration rate is increased at 4 months of age to a similar level as in single Ins2Akita homozygotes (J:198186)
• by 6 months of age, glomerular filtration rate is decreased compared to controls, with an overall 50% decline compared to at 4 months (J:198186)
• glomerular filtration rate is increased at 4 months of age to a similar level as in single Ins2Akita homozygotes (J:198186)
• by 6 months of age, glomerular filtration rate is decreased compared to controls, with an overall 50% decline compared to at 4 months (J:198186)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:198186


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory