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Phenotypes Associated with This Genotype
Genotype
MGI:5508557
Allelic
Composition
Tg(Thy1-VCP*A232E)BMaki/0
Genetic
Background
involves: C57BL/6J
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants show impaired contextual fear conditioning at 6 and 12 months of age
• object recognition at 12 months of age is impaired in recalling a familiar object
• mutants show impairment in Morris water maze acquisition at 6 and 12 months of age
• probe trial escape latency in the Morris water maze indicates impaired memory retention at 12 months of age

nervous system
• abnormal accumulation of TDP-43 in neurons; focal accumulation of TDP-43 is co-localized with stress granules and/or ubiquitin in the cortex; accumulation of TDP-43 is predominantly of the high-molecular weight form
• mutants exhibit abnormal accumulation of TDP-43 in the cytoplasm of neurons
• mutants show an increase in the number of neurons with ubiquitin cytosolic inclusions
• however, neurodegeneration is not observed


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory