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Phenotypes Associated with This Genotype
Genotype
MGI:5507884
Allelic
Composition
Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu
Genetic
Background
involves: C57BL/6 * C57BL/6N
Cell Lines HEPD0529_1_B07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smug1tm1a(EUCOMM)Hmgu mutation (0 available); any Smug1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit normal life expectancy

cellular
• mice lack 5-hydroxymethyluracil excision activity compared with wild-type mice
• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells
• mouse embryonic fibroblasts are resistant to 5-hydroxymethyluridine toxicity compared with wild-type cells

homeostasis/metabolism
• mice lack 5-hydroxymethyluracil excision activity compared with wild-type mice
• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory