Mouse Genome Informatics
hm
    Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
reproductive system
• increased vacuolization at 12 months
• at 12 months but not 8 weeks (J:198260)
• at 12 months but not 8 weeks (J:198260)
• increased vacuolization at 12 months (J:198260)
• lack or reduced number of spermatids in seminiferous tubules at 12 months (J:198260)
• at 12 months but not 8 weeks (J:198260)

immune system
N
• T cell and stimulated B cell proliferation is normal (J:198260)
• directly impaired class switch recombination
• lower frequency of Smu-Sgamma1 switch recombination
• increased frequency of long nucleotide insertions at the class switch recombination junctions
• at 6 to 8 weeks and 9 to 12 months
• fewer IgG1-expressing B cells in Peyer's patches
• reduced secretion from B cells stimulated with LPS and IL4
• reduced secretion from B cells stimulated with LPS and IL4
• fewer IgG3-expressing B cells in Peyers patches
• reduced secretion from B cells stimulated with LPS and IL4

cellular
• irradiated mouse embryonic fibroblasts accumulate at the G2/M phase
• however, activation of the G1/S checkpoint is normal
• spontaneous chromosome aberration in LPS stimulated B cells
• following exposure to ionizing radiation

tumorigenesis
N
• mice do not develop tumors over a 1 year period (J:198260)

endocrine/exocrine glands
• increased vacuolization at 12 months
• at 12 months but not 8 weeks (J:198260)
• at 12 months but not 8 weeks (J:198260)

hematopoietic system
• directly impaired class switch recombination
• lower frequency of Smu-Sgamma1 switch recombination
• increased frequency of long nucleotide insertions at the class switch recombination junctions
• at 6 to 8 weeks and 9 to 12 months
• fewer IgG1-expressing B cells in Peyer's patches
• reduced secretion from B cells stimulated with LPS and IL4
• reduced secretion from B cells stimulated with LPS and IL4
• fewer IgG3-expressing B cells in Peyers patches
• reduced secretion from B cells stimulated with LPS and IL4

Mouse Models of Human Disease
OMIM IDRef(s)
Riddle Syndrome 611943 J:198260