About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5501108
Allelic
Composition
Engtm2.1Hma/Engtm2.1Hma
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm2.1Hma mutation (0 available); any Eng mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice co-injected with a Cre recombinase and a VEGF expressing adenovirus exhibit malformed vessels and increased cerebrovascular density in the brain at the injection site resembling arteriovenous malformations
• however, mutants co-injected with a Cre recombinase and a VEGF expressing adenovirus exhibit a similar degree of angiogenesis as in wild-type mice injected with the VEGF adenovirus
• co-injection of a Cre recombinase and a VEGF expressing adenovirus induces less cerebrovascular dysplasia in mutants than in similarly injected Acvrl1tm2.1Spo homozygotes, however gene deletion efficiency is lower in this mutant and when gene deletion efficiency is the same, then these mutants show more dysplastic vessels per gene copy than the Acvrl1 mutant

nervous system
• mice co-injected with a Cre recombinase and a VEGF expressing adenovirus exhibit malformed vessels and increased cerebrovascular density in the brain at the injection site resembling arteriovenous malformations
• however, mutants co-injected with a Cre recombinase and a VEGF expressing adenovirus exhibit a similar degree of angiogenesis as in wild-type mice injected with the VEGF adenovirus
• co-injection of a Cre recombinase and a VEGF expressing adenovirus induces less cerebrovascular dysplasia in mutants than in similarly injected Acvrl1tm2.1Spo homozygotes, however gene deletion efficiency is lower in this mutant and when gene deletion efficiency is the same, then these mutants show more dysplastic vessels per gene copy than the Acvrl1 mutant

Mouse Models of Human Disease
OMIM ID Ref(s)
Arteriovenous Malformations of the Brain 108010 J:196810


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/19/2016
MGI 6.03
The Jackson Laboratory