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Phenotypes Associated with This Genotype
Genotype
MGI:5499734
Allelic
Composition
Myh9tm1.1(MYH9*)Mjk/Myh9+
Genetic
Background
B6.Cg-Myh9tm1.1(MYH9*)Mjk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh9tm1.1(MYH9*)Mjk mutation (0 available); any Myh9 mutation (218 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• with mild inflammatory cellular infiltration
• liquefaction of lens fibers
• bilateral in some mice with swelling, lens epithelial proliferation and degeneration, and liquefaction of lens fibers
• lens epithelial proliferation and degeneration
• liquefaction of lens fibers
• mild inflammatory cellular infiltration

hematopoietic system
• contain Myh9 aggregates
• increased diameter
• macrothrombocytopenia

hearing/vestibular/ear
• progressive hearing loss with age

homeostasis/metabolism

renal/urinary system

immune system
• contain Myh9 aggregates
• mild inflammatory cellular infiltration

cardiovascular system
• with mild inflammatory cellular infiltration

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
MYH-9 related disease DOID:0060651 OMIM:155100
J:175367


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory