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Phenotypes Associated with This Genotype
Genotype
MGI:5495915
Allelic
Composition
Ddctm1.1Nwlh/Ddctm1.1Nwlh
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddctm1.1Nwlh mutation (0 available); any Ddc mutation (108 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• half of mice are born alive

behavior/neurological
• adult mice exhibit impaired motor learning compared with wild-type mice
• in an elevated plus maze
• in an open field
• resting tremors
• on a rotarod in young and adult mice with gradual improvement after weaning
• in the daytime, adult mice spend less time hanging than wild-type mice
• in daytime and nighttime
• apomorphine-treated mice exhibit increased activity and rearing compared with wild-type mice
• apomorphine-treated mice exhibit increased activity and rearing compared with wild-type mice
• poor maternal care

homeostasis/metabolism
• L-DOPA accumulates, especially in young mice
• in the brain
• lower norepinephrine levels in the brain
• in the brain

cardiovascular system
• in adult mice

growth/size/body
• at P10 with gradual improvement after weaning
• from birth to weaning

vision/eye

nervous system
• L-DOPA accumulates, especially in young mice
• in the brain
• lower DOPAC, HVA and 5-HIAA neurotransmitter metabolites in the brain
• adult neurotransmitter levels are higher than in infants

Mouse Models of Human Disease
OMIM ID Ref(s)
Aromatic L-Amino Acid Decarboxylase Deficiency 608643 J:197646


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory