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Phenotypes Associated with This Genotype
Genotype
MGI:5495915
Allelic
Composition
Ddctm1.1Nwlh/Ddctm1.1Nwlh
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddctm1.1Nwlh mutation (0 available); any Ddc mutation (94 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• half of mice are born alive (J:197646)
• half of mice are born alive (J:197646)

behavior/neurological
• in an elevated plus maze (J:197646)
• in an elevated plus maze (J:197646)
• in an open field (J:197646)
• in an open field (J:197646)
• adult mice exhibit impaired motor learning compared with wild-type mice (J:197646)
• adult mice exhibit impaired motor learning compared with wild-type mice (J:197646)
• resting tremors (J:197646)
• resting tremors (J:197646)
• on a rotarod in young and adult mice with gradual improvement after weaning (J:197646)
• in the daytime, adult mice spend less time hanging than wild-type mice (J:197646)
• on a rotarod in young and adult mice with gradual improvement after weaning (J:197646)
• in the daytime, adult mice spend less time hanging than wild-type mice (J:197646)
• in daytime and nighttime (J:197646)
• in daytime and nighttime (J:197646)
• dyskinesia (J:197646)
• dyskinesia (J:197646)
• apomorphine-treated mice exhibit increased activity and rearing compared with wild-type mice (J:197646)
• apomorphine-treated mice exhibit increased activity and rearing compared with wild-type mice (J:197646)
• apomorphine-treated mice exhibit increased activity and rearing compared with wild-type mice (J:197646)
• apomorphine-treated mice exhibit increased activity and rearing compared with wild-type mice (J:197646)
• poor maternal care (J:197646)
• poor maternal care (J:197646)

homeostasis/metabolism
• L-DOPA accumulates, especially in young mice (J:197646)
• L-DOPA accumulates, especially in young mice (J:197646)
• in the brain (J:197646)
• in the brain (J:197646)
• lower norepinephrine levels in the brain (J:197646)
• lower norepinephrine levels in the brain (J:197646)
• in the brain (J:197646)
• in the brain (J:197646)

cardiovascular system
• in adult mice (J:197646)
• in adult mice (J:197646)
• in adult mice (J:197646)
• in adult mice (J:197646)

growth/size/body
• at P10 with gradual improvement after weaning (J:197646)
• at P10 with gradual improvement after weaning (J:197646)
• from birth to weaning (J:197646)
• from birth to weaning (J:197646)

vision/eye

nervous system
• L-DOPA accumulates, especially in young mice (J:197646)
• L-DOPA accumulates, especially in young mice (J:197646)
• in the brain (J:197646)
• in the brain (J:197646)
• lower DOPAC, HVA and 5-HIAA neurotransmitter metabolites in the brain (J:197646)
• adult neurotransmitter levels are higher than in infants (J:197646)
• lower DOPAC, HVA and 5-HIAA neurotransmitter metabolites in the brain (J:197646)
• adult neurotransmitter levels are higher than in infants (J:197646)

Mouse Models of Human Disease
OMIM ID Ref(s)
Aromatic L-Amino Acid Decarboxylase Deficiency 608643 J:197646


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory