Mouse Genome Informatics
hm
    Ddctm1.1Nwlh/Ddctm1.1Nwlh
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• half of mice are born alive

behavior/neurological
• in an elevated plus maze
• in an open field
• adult mice exhibit impaired motor learning compared with wild-type mice
• resting tremors
• on a rotarod in young and adult mice with gradual improvement after weaning
• in the daytime, adult mice spend less time hanging than wild-type mice
• in daytime and nighttime
• apomorphine-treated mice exhibit increased activity and rearing compared with wild-type mice
• apomorphine-treated mice exhibit increased activity and rearing compared with wild-type mice
• poor maternal care (J:197646)

homeostasis/metabolism
• L-DOPA accumulates, especially in young mice
• in the brain
• lower norepinephrine levels in the brain
• in the brain

cardiovascular system
• in adult mice

growth/size
• at P10 with gradual improvement after weaning
• from birth to weaning

vision/eye

nervous system
• L-DOPA accumulates, especially in young mice
• in the brain
• lower DOPAC, HVA and 5-HIAA neurotransmitter metabolites in the brain
• adult neurotransmitter levels are higher than in infants

Mouse Models of Human Disease
OMIM IDRef(s)
Aromatic L-Amino Acid Decarboxylase Deficiency 608643 J:197646