Analysis Tools
mortality/aging
integument
|
• 2-fold increase in trans-epidermal water loss
• however, outside-in epidermal barrier is normal
|
|
• mild skin defect
|
|
• reduced number of intact cornified envelopes
• however, treatment with IL18-blocking antibodies rescues number of intact cornified envelopes
|
immune system
|
• increased IL33 in the serum of newborn mice
|
|
• in newborn mice but not epidermal extracts
|
|
• increased IL33 in epidermal extracts
|
cardiovascular system
|
• increased vascularization at the dermal/epidermal interface indicated by increased PECAM staining
|
|
• leaky capillary in the lungs at P0
|
growth/size/body
weight loss
(
J:200244
)
|
• mild postnatally
|
homeostasis/metabolism
|
• increased IL33 in the serum of newborn mice
|
|
• in newborn mice but not epidermal extracts
|
|
• 2-fold increase in trans-epidermal water loss
• however, outside-in epidermal barrier is normal
|
nervous system
|
• reduced
|
hematopoietic system
|
• in the lungs at P0
|
