Phenotypes Associated with This Genotype

Genotype
MGI:5494692

• Allelic Composition: Myo5a^{tm1e(KOMP)Wtsi}/Myo5a^{tm1e(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0034_4_C03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Diluted coat color in Myo5a^{tm1e(KOMP)Wtsi}/Myo5a^{tm1e(KOMP)Wtsi} mice

mortality/aging

preweaning lethality, incomplete penetrance ( J:195694 )

• fewer than expected mice are obtained from mating heterozygous mice

pigmentation

diluted coat color ( J:195694 )

• lighter grey coat color than wild-type mice

hypopigmentation ( J:195694 )

• lighter grey coat color than wild-type mice

hematopoietic system

hematopoietic system phenotype ( J:195694 )

N • mice exhibit normal platelet count, mean platelet volume, red blood cell count, hematocrit, mean corpuscular volume and white blood cell count

N • platelets exhibit normal granule biogenesis and secretion, integrin activation, calcium signaling and spreading

integument

diluted coat color ( J:195694 )

• lighter grey coat color than wild-type mice