Phenotypes Associated with This Genotype

Genotype
MGI:5491492

• Allelic Composition: Satb1^{tm1a(EUCOMM)Hmgu}/Satb1^{tm1a(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N
• Cell Lines: HEPD0534_5_E11

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:196342 )

• mice die within three weeks of birth

nervous system

nervous system phenotype ( J:196342 )

N • mice exhibit normal cortical lamination

abnormal brain interneuron morphology ( J:196342 )

• reduced numbers of somatostatin+ cortical interneurons at P15

• however, the number of tangential migrating interneurons during embryogenesis is normal

growth/size/body

postnatal growth retardation ( J:196342 )

• mice fail to thrive