Analysis Tools
nervous system
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• irregularities are detected at the axon-myelin interface including; irregular width of the extracellular periaxonal space and occasional apparent fusion of the adaxonal glial membrane with the axonal membrane
• occasionally the axon?myelin apposition is severely disturbed
• rarely invaginations of the oligodendroglial plasma membrane into the axoplasm are seen
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• double myelination is occasionally seen
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behavior/neurological
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N |
• no defects in motor function are detected in mice at up to 24 months of age
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