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Phenotypes Associated with This Genotype
Genotype
MGI:5487278
Allelic
Composition
Cacna1atm3Maag/Cacna1a+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1atm3Maag mutation (0 available); any Cacna1a mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice show increased vulnerability to ischemic stroke, developing an earlier onset of anoxic depolarization after filament occlusion of the middle cerebral artery
• transient filament occlusion of the middle cerebral artery for 30 minutes produces larger infarcts than in wild-type mice
• females show more striking increases in infarct volume than males
• treatment with the NMDA antagonist MK-801 significantly reduces infarct volume by 45% in mutants compared with only 23% in wild-type mice

mortality/aging
• females exhibit more than 60% mortality between 24 and 96 hours following transient filament occlusion of the cerebral artery for 30 minutes

nervous system
• mice show increased vulnerability to ischemic stroke, developing an earlier onset of anoxic depolarization after filament occlusion of the middle cerebral artery
• transient filament occlusion of the middle cerebral artery for 30 minutes produces larger infarcts than in wild-type mice
• females show more striking increases in infarct volume than males
• treatment with the NMDA antagonist MK-801 significantly reduces infarct volume by 45% in mutants compared with only 23% in wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Migraine, Familial Hemiplegic, 1; FHM1 141500 J:193793


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory