Mouse Genome Informatics
ht
    Cacna1atm3Maag/Cacna1a+
involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• mice show increased vulnerability to ischemic stroke, developing an earlier onset of anoxic depolarization after filament occlusion of the middle cerebral artery
• transient filament occlusion of the middle cerebral artery for 30 minutes produces larger infarcts than in wild-type mice
• females show more striking increases in infarct volume than males
• treatment with the NMDA antagonist MK-801 significantly reduces infarct volume by 45% in mutants compared with only 23% in wild-type mice

mortality/aging
• females exhibit more than 60% mortality between 24 and 96 hours following transient filament occlusion of the cerebral artery for 30 minutes (J:193793)

nervous system
• mice show increased vulnerability to ischemic stroke, developing an earlier onset of anoxic depolarization after filament occlusion of the middle cerebral artery
• transient filament occlusion of the middle cerebral artery for 30 minutes produces larger infarcts than in wild-type mice
• females show more striking increases in infarct volume than males
• treatment with the NMDA antagonist MK-801 significantly reduces infarct volume by 45% in mutants compared with only 23% in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Migraine, Familial Hemiplegic, 1; FHM1 141500 J:193793