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Phenotypes Associated with This Genotype
Genotype
MGI:5476847
Allelic
Composition
Tg(TARDBP)#Jpj/0
Genetic
Background
involves: C3H * C57BL/6
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phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the passive avoidance test, mutants exhibit severe cognitive impairments after 7 months of age and especially in the 11th and 13th months
• mice exhibit a learning impairment in the Barnes maze test at 10 months of age, showing a reduction in the time spent in the target quadrant and increased primary errors
• in the probe trial, mutants show a reduction in the time spent in the target quadrant and an increase in the total number of errors
• mice show reduction in latency in the accelerating rotarod tests starting at around 42 weeks of age, indicating age-related motor deficits

nervous system
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is less pronounced than in mice expressing the transgene with the G348C mutation
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is less pronounced than in mice expressing the transgene with the G348C mutation
• 5% increase (an increase of 50 axons) in the number of motor axons with 1-3 um caliber and a 6% decrease (a decrease of 60 axons) in the number of motor axons with 6-9 um caliber in 10 month old mutants
• 5% of analyzed neuromuscular junctions are denervated in 10 month old mutants, while over 20% are partially denervated

hematopoietic system
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is less pronounced than in mice expressing the transgene with the G348C mutation

immune system
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is less pronounced than in mice expressing the transgene with the G348C mutation


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory