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Phenotypes Associated with This Genotype
Genotype
MGI:5476832
Allelic
Composition
Tg(TARDBP*A315T)#Jpj/0
Genetic
Background
involves: C3H * C57BL/6
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phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the passive avoidance test, mutants exhibit severe cognitive impairments after 7 months of age and especially in the 11th and 13th months (J:195184)
• in the passive avoidance test, mutants exhibit severe cognitive impairments after 7 months of age and especially in the 11th and 13th months (J:195184)
• mice show reduction in latency in the accelerating rotarod tests starting at around 42 weeks of age, indicating age-related motor deficits (J:195184)
• mice show reduction in latency in the accelerating rotarod tests starting at around 42 weeks of age, indicating age-related motor deficits (J:195184)

nervous system
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is less pronounced than in mice expressing the transgene with the G348C mutation (J:195184)
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is less pronounced than in mice expressing the transgene with the G348C mutation (J:195184)
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is less pronounced than in mice expressing the transgene with the G348C mutation (J:195184)
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is less pronounced than in mice expressing the transgene with the G348C mutation (J:195184)
• 7% increase (an increase of 70 axons) in the number of motor axons with 1-3 um caliber and a 8% decrease (a decrease of 80 axons) in the number of motor axons with 6-9 um caliber in 10 month old mutants (J:195184)
• 7% increase (an increase of 70 axons) in the number of motor axons with 1-3 um caliber and a 8% decrease (a decrease of 80 axons) in the number of motor axons with 6-9 um caliber in 10 month old mutants (J:195184)
• mice develop ubiquitinated and TARDBP+ inclusions in the spinal cord, cortex, and hippocampus by 10 months of age (J:195184)
• abnormal accumulation of neurofilament and peripherin proteins in inclusions in large motor neurons and the brain at 10 months of age (J:195184)
• mice develop ubiquitinated and TARDBP+ inclusions in the spinal cord, cortex, and hippocampus by 10 months of age (J:195184)
• abnormal accumulation of neurofilament and peripherin proteins in inclusions in large motor neurons and the brain at 10 months of age (J:195184)

hematopoietic system
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is less pronounced than in mice expressing the transgene with the G348C mutation (J:195184)
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is less pronounced than in mice expressing the transgene with the G348C mutation (J:195184)

immune system
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is less pronounced than in mice expressing the transgene with the G348C mutation (J:195184)
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is less pronounced than in mice expressing the transgene with the G348C mutation (J:195184)


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory