About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5476766
Allelic
Composition		 Nuggctm1Diaz/Nuggctm1Diaz
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (42 available)
Nuggctm1Diaz mutation (0 available); any Nuggc mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal somatic hypermutation frequency ( J:190402 )
• Peyer's patch B cells exhibit increased mutation frequency (G to C transitions) at JH4 downstream regions at immunoglobulin and non-immunoglobulin loci compared with wild-type cells

immune system
immune system phenotype ( J:190402 )
N
• mice exhibit normal B cell development, germinal center formation and class switch recombination
abnormal somatic hypermutation frequency ( J:190402 )
• Peyer's patch B cells exhibit increased mutation frequency (G to C transitions) at JH4 downstream regions at immunoglobulin and non-immunoglobulin loci compared with wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory