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Phenotypes Associated with This Genotype
Genotype
MGI:5476673
Allelic
Composition
Tg(Eno2-MFN2*R94Q)L87Ugfm/Tg(Eno2-MFN2*R94Q)L87Ugfm
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Eno2-MFN2*R94Q)L87Ugfm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at 5 months with phenotypic variation (J:173431)
• at 5 months with phenotypic variation (J:173431)
• mice stand very low on their legs and tail dragging (J:173431)
• mice stand very low on their legs and tail dragging (J:173431)
• with everted paws (J:173431)
• with everted paws (J:173431)

nervous system
N
• mice exhibit normal cerebellum morphology (J:173431)
• mice exhibit normal cerebellum morphology (J:173431)
• at 12 months, the proportion of small and medium axons is increased while proportion of large axons is decreased compared to in control mice (J:173431)
• at 12 months, the proportion of small and medium axons is increased while proportion of large axons is decreased compared to in control mice (J:173431)

cellular
• in medium and small myelinated axons at 12 months (J:173431)
• however, large axons exhibit normal numbers of mitochondria (J:173431)
• in medium and small myelinated axons at 12 months (J:173431)
• however, large axons exhibit normal numbers of mitochondria (J:173431)

Mouse Models of Human Disease
OMIM ID Ref(s)
Charcot-Marie-Tooth Disease, Axonal, Type 2A2; CMT2A2 609260 J:173431


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory