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Phenotypes Associated with This Genotype
Genotype
MGI:5475250
Allelic
Composition
Slc27a4pskn/Slc27a4pskn
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc27a4pskn mutation (0 available); any Slc27a4 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Alteration of skin structure at the earlier stages of Slc27a4pskn/Slc27a4pskn mice

mortality/aging
• within a few hours of birth

integument
• aberrant epidermal differentiation
• massive
• change in patterning, size and distribution
• increased number of cell layers
• on the toes and tip of the tail in some mice at birth
• mice are born with smooth, tight and shiny skin
• skin cracking upon stretching
• exterior surface of the skin and the epidermal-dermal junction is flattened
• at birth
• at birth

behavior/neurological
• newborns are immobilized in fetal position due to tight skin

cellular

craniofacial

digestive/alimentary system

skeleton

growth/size/body

Mouse Models of Human Disease
OMIM ID Ref(s)
Ichthyosis Prematurity Syndrome; IPS 608649 J:194779


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory