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Phenotypes Associated with This Genotype
Genotype
MGI:5474860
Allelic
Composition		 Rhotm2.1Kpal/Rho+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm2.1Kpal mutation (0 available); any Rho mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Progressive retinal degeneration in heterozygous and homozygous Rhotm2.1Kpal mice

vision/eye
retina photoreceptor degeneration ( J:194158 )
• intermediate phenotype
thin retina outer nuclear layer ( J:194158 )
• intermediate phenotype
• nearly complete lost by 10 months
abnormal cone electrophysiology ( J:194158 )
• gradual decline after 2 months
abnormal rod electrophysiology ( J:194158 )
• gradual decline after 2 months

nervous system
retina photoreceptor degeneration ( J:194158 )
• intermediate phenotype

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory