Phenotypes Associated with This Genotype

Genotype
MGI:5474630

• Allelic Composition: Emv72^a/Emv72^a
• Genetic Background: involves: BALB/cAnNCr * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytotoxic T cell physiology ( J:194735 )

• T cells exhibit decreased CT26 cell lysis (AH1 antigen) compared with cells from Emv72^b mice

neoplasm

increased tumor growth/size ( J:194735 )

• most mice injected CT26 tumors cells develop tumors within two weeks unlike Emv72^b mice

• however, younger mice exhibit protection from tumor development

hematopoietic system

abnormal cytotoxic T cell physiology ( J:194735 )

• T cells exhibit decreased CT26 cell lysis (AH1 antigen) compared with cells from Emv72^b mice