Phenotypes Associated with This Genotype

Genotype
MGI:5474628

• Allelic Composition: Emv72^b/Emv72^b
• Genetic Background: CAnNCr.B6NCr-Emv72^b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell morphology ( J:194735 )

• mice exhibit increased numbers and avidity of responding antigen-specific T cells after vaccination with tumor-associated antigen

abnormal cytotoxic T cell physiology ( J:194735 )

• mice exhibit increased quantity and quality AH1-specifc T cell response compared with Emv72^a mice

neoplasm

decreased tumor growth/size ( J:194735 )

• only half of mice injected CT26 tumors cells develop tumors compared with most Emv72^a mice

• however, depletion of CD4+ of CD8+ T cells increases tumor development

hematopoietic system

abnormal T cell morphology ( J:194735 )

• mice exhibit increased numbers and avidity of responding antigen-specific T cells after vaccination with tumor-associated antigen

abnormal cytotoxic T cell physiology ( J:194735 )

• mice exhibit increased quantity and quality AH1-specifc T cell response compared with Emv72^a mice