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Phenotypes Associated with This Genotype
Genotype
MGI:5473606
Allelic
Composition
Frem1eyes2/Frem1eyes2
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frem1eyes2 mutation (0 available); any Frem1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at P28

vision/eye
• in 18 of 32 mice
• unilateral and bilateral

muscle
• reduced cell proliferation in the mid-diaphragm at E14.5
• however, thickness is normal
• in the anterior midline directly behind the sternum 15 of 32 mice

renal/urinary system
• in 5 of 32 mice

liver/biliary system
• sometimes fused to the membranous sac covering the herniated viscera

digestive/alimentary system
• in some mice

endocrine/exocrine glands
• sometimes fused to the membranous sac covering the herniated viscera

respiratory system
• the cranial, medial, and caudal lobes of the right lung are partially or completely fused in 11/39 affected mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Diaphragmatic Hernia, Congenital 142340 J:192553


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory