Mouse Genome Informatics
hm
    Frem1eyes2/Frem1eyes2
involves: 129S6/SvEvTac * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• fewer than expected mice are present at P28

vision/eye
• in 18 of 32 mice
• unilateral and bilateral

muscle
• reduced cell proliferation in the mid-diaphragm at E14.5
• however, thickness is normal
• in the anterior midline directly behind the sternum 15 of 32 mice

renal/urinary system
• in 5 of 32 mice

liver/biliary system
• sometimes fused to the membranous sac covering the herniated viscera

digestive/alimentary system
• in some mice

endocrine/exocrine glands
• sometimes fused to the membranous sac covering the herniated viscera

respiratory system
• the cranial, medial, and caudal lobes of the right lung are partially or completely fused in 11/39 affected mice

Mouse Models of Human Disease
OMIM IDRef(s)
Diaphragmatic Hernia, Congenital 142340 J:192553