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Phenotypes Associated with This Genotype
Genotype
MGI:5473606
Allelic
Composition
Frem1eyes2/Frem1eyes2
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frem1eyes2 mutation (0 available); any Frem1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at P28 (J:192553)
• fewer than expected mice are present at P28 (J:192553)

vision/eye
• in 18 of 32 mice (J:192553)
• in 18 of 32 mice (J:192553)
• unilateral and bilateral (J:192553)
• unilateral and bilateral (J:192553)

muscle
• reduced cell proliferation in the mid-diaphragm at E14.5 (J:192553)
• however, thickness is normal (J:192553)
• reduced cell proliferation in the mid-diaphragm at E14.5 (J:192553)
• however, thickness is normal (J:192553)
• in the anterior midline directly behind the sternum 15 of 32 mice (J:192553)
• in the anterior midline directly behind the sternum 15 of 32 mice (J:192553)

renal/urinary system
• in 5 of 32 mice (J:192553)
• in 5 of 32 mice (J:192553)

liver/biliary system
• sometimes fused to the membranous sac covering the herniated viscera (J:192553)
• sometimes fused to the membranous sac covering the herniated viscera (J:192553)

digestive/alimentary system
• in some mice (J:192553)
• in some mice (J:192553)

endocrine/exocrine glands
• sometimes fused to the membranous sac covering the herniated viscera (J:192553)
• sometimes fused to the membranous sac covering the herniated viscera (J:192553)

respiratory system
• the cranial, medial, and caudal lobes of the right lung are partially or completely fused in 11/39 affected mice (J:200175)
• the cranial, medial, and caudal lobes of the right lung are partially or completely fused in 11/39 affected mice (J:200175)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diaphragmatic Hernia, Congenital 142340 J:192553


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory