Phenotypes Associated with This Genotype

Genotype
MGI:5470233

• Allelic Composition: Polg2^tm1.1Wcc/Polg2^tm1.1Wcc
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:192568 )

• mice die between E8.0 and E8.5

cellular

abnormal mitochondrial morphology ( J:192568 )

• increase in fatty droplet with swollen and disorganized cristae

decreased mitochondrial DNA content ( J:192568 )

disorganized mitochondrial cristae ( J:192568 )

• swollen and disorganized cristae

abnormal respiratory electron transport chain ( J:192568 )

• complete lack of COX1(mt-Co1) activity

embryo

failure of initiation of embryo turning ( J:192568 )