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Phenotypes Associated with This Genotype
Genotype
MGI:5470168
Allelic
Composition
Zic3tm2.1Jwb/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (42 available)
Zic3tm2.1Jwb mutation (1 available); any Zic3 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• despite normal numbers at E15.5, fewer than expected mice at weaning

cardiovascular system
• separate entrance of hepatic veins in some mice
• in 5 of 32 mice at E9.5
• in some mice
• atrium isomerism in some mice
• in some mice
• in some mice

digestive/alimentary system
• in 4 of 38 mice at E15.5
• in some mice
• midline and right-sided stomach in some mice
• in some mice

embryo
• in some mice at E9.5
• in 14 of 32 mice
• in 4 of 38 mice at E15.5

growth/size/body
• in 4 of 38 mice at E15.5
• in 14 of 32 mice
• laterality defects in 2 of 8 mice
• in some mice

nervous system
• in 4 of 38 mice at E15.5
• in 4 of 38 mice at E15.5

behavior/neurological
• in some mice

vision/eye
• in some mice

skeleton

respiratory system
• pulmonary isomerism in some mice

limbs/digits/tail

craniofacial
• in 4 of 38 mice at E15.5


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory