Mouse Genome Informatics
hm
    Otoatm1Gpr/Otoatm1Gpr
involves: 129S/SvEv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

The tectorial membrane of Otoatm1Gpr/Otoatm1Gpr mice is detached from spiral limbus

hearing/vestibular/ear
N
• mice exhibit normal cochlear microphonic potentials and cochlear amplification (J:192263)
• absent Hensen's stripe
• thin lateral-most region, frequently fenestrated
• slightly tilted with the lateral region displaced medially
• however, the orientation and organization of hair cells is normal
• from the spiral limbus
• elevated cochlear nerve compound action potential threshold
• elevated cochlear nerve compound action potential threshold

nervous system
• elevated cochlear nerve compound action potential threshold

Mouse Models of Human Disease
OMIM IDRef(s)
Deafness, Autosomal Recessive 22; DFNB22 607039 J:192263