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Phenotypes Associated with This Genotype
Genotype
MGI:5469422
Allelic
Composition
Otoatm1Gpr/Otoatm1Gpr
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otoatm1Gpr mutation (2 available); any Otoa mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

The tectorial membrane of Otoatm1Gpr/Otoatm1Gpr mice is detached from spiral limbus

hearing/vestibular/ear
N
• mice exhibit normal cochlear microphonic potentials and cochlear amplification
• absent Hensen's stripe
• thin lateral-most region, frequently fenestrated
• slightly tilted with the lateral region displaced medially
• however, the orientation and organization of hair cells is normal
• from the spiral limbus
• elevated cochlear nerve compound action potential threshold
• elevated cochlear nerve compound action potential threshold

nervous system
• elevated cochlear nerve compound action potential threshold

Mouse Models of Human Disease
OMIM ID Ref(s)
Deafness, Autosomal Recessive 22; DFNB22 607039 J:192263


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory