Phenotypes Associated with This Genotype

Genotype
MGI:5468973

• Allelic Composition: Nlrp3^tm1Vmd/Nlrp3^tm1Vmd
• Genetic Background: B6.B6N-Nlrp3^tm1Vmd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:294930 )

N • normal inflammatory response by bone marrow derived macrophages exposed to cytosolic Legionella pneumophila flagellin

decreased circulating interleukin-1 beta level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

decreased circulating interleukin-18 level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

decreased interleukin-1 beta secretion ( J:193522 )

• from LPS-primed bone marrow-derived macrophages stimulated with E. coli, C. rodentium and C. cholerae

decreased susceptibility to endotoxin shock ( J:193522 )

• mice treated with LPS challenge in a model of acute septic shock exhibit reduced serum levels of IL1b and IL18 compared with controls

• however, mice do not survive beyond 20 hours and serum levels of IL1a are increased

homeostasis/metabolism

decreased circulating interleukin-1 beta level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

decreased circulating interleukin-18 level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock