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Phenotypes Associated with This Genotype
Genotype
MGI:5468971
Allelic
Composition
Casp1tm1Sesh/Casp1tm1Sesh
Casp4del/Casp4del
Genetic
Background
B6.129S2(NOD)-Casp1tm1Sesh Casp4del
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Sesh mutation (4 available); any Casp1 mutation (27 available)
Casp4del mutation (3 available); any Casp4 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• in response to LPS challenge in a model of acute septic shock

immune system
• impaired cell death in response to ATP, Clostridium difficile toxin B, CTB and E. coli
• in response to LPS challenge in a model of acute septic shock
• in response to LPS challenge in a model of acute septic shock
• in response to LPS challenge in a model of acute septic shock
• from LPS-primed bone marrow-derived macrophage in response to ATP, C. difficile, CTB and E. coli
• LPS-primed bone marrow-derived macrophages fail to produce IL1b and IL18 in response to ATP, Clostridium difficile toxin B, cholera toxin B (CTB) or E. coli unlike controls
• LPS-primed bone marrow-derived macrophages fail to produce IL1b and IL18 in response to ATP, Clostridium difficile toxin B, cholera toxin B (CTB) or E. coli unlike controls
• mice are resistant to LPS challenge in a model of acute septic shock with reduced mortality and serum levels of IL1b, IL1a and IL18

cellular
• of intestinal epithelial cells (IECs) after oral rotavirus inoculation of 8 day old pups
• impaired cell death in response to ATP, Clostridium difficile toxin B, CTB and E. coli

homeostasis/metabolism
• in response to LPS challenge in a model of acute septic shock
• in response to LPS challenge in a model of acute septic shock
• in response to LPS challenge in a model of acute septic shock
• in response to LPS challenge in a model of acute septic shock

hematopoietic system
• impaired cell death in response to ATP, Clostridium difficile toxin B, CTB and E. coli


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory