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Phenotypes Associated with This Genotype
Genotype
MGI:5468673
Allelic
Composition
Trp63tm1Cmis/Trp63+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm1Cmis mutation (0 available); any Trp63 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

integument
• compromised desmosomes in the epidermis
• defects in cell-cell adhesion
• however, defects are alleviated by EGFR inhibition

craniofacial

digestive/alimentary system

growth/size/body

Mouse Models of Human Disease
OMIM ID Ref(s)
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate 106260 J:191121


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory