Phenotypes Associated with This Genotype

Genotype
MGI:5468267

• Allelic Composition: Gfi1^{tm5.1(GFI1*)Tmo}/Gfi1^{tm5.1(GFI1*)Tmo}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:192927 )

N • mice exhibit normal lymphoid differentiation in the bone marrow, spleen and thymus and normal numbers of hematopoietic stem cells

abnormal definitive hematopoiesis ( J:192927 )

• increased granulomonocytic progenitors with a higher proportion in S/G2/M phase

increased monocyte cell number ( J:192927 )

• with a tendency towards lower numbers of granulocytes

cellular

abnormal mitosis ( J:192927 )

• a higher proportion of granulomonocytic progenitors are undergoing cell cycling compared with wild-type mice or Gfi1^{tm6.1(GFI1)Tmo} homozygotes

immune system

increased monocyte cell number ( J:192927 )

• with a tendency towards lower numbers of granulocytes