Phenotypes Associated with This Genotype

Genotype
MGI:5467997

• Allelic Composition: Wnt16^tm1Lex/Wnt16^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

decreased femoral compact bone area ( J:188156 )

♀ • decreased compact bone area in the femoral diaphysis of female mice

skeleton

skeleton phenotype ( J:188156 )

N • mice exhibit normal trabecular bone volume fraction in the fifth lumbar vertebrae

N • male mice exhibit normal microCT parameters of the femoral shaft and fifth lumbar vertebrae

decreased femoral compact bone area ( J:188156 )

♀ • decreased compact bone area in the femoral diaphysis of female mice

decreased compact bone thickness ( J:188156 )

• substantial in the femoral diaphysis of female mice

• trend in the femoral diaphysis of male mice

decreased bone strength ( J:188156 )

• in the femoral diaphysis of male mice

• in the femoral diaphysis, femur and tibia of female mice