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Phenotypes Associated with This Genotype
Genotype
MGI:5466506
Allelic
Composition
Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic
Background
FVB.129P2-Zdhhc13Gt(AC0492)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zdhhc13Gt(AC0492)Wtsi mutation (0 available); any Zdhhc13 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• normal survival

nervous system
• in the striatum at 6 months
• from 3 to 12 months
• reduced volume at 3 and 6 months
• reduced volume at 6 months
• progressive reduction in volume from 3 to 12 months
• reduced volume at 3 and 6 months
• progressive reduction in volume from 3 to 12 months
• reduced weight from 3 to 12 months
• in the striatum at 6 months

behavior/neurological
• mice exhibit impaired motor learning only on day 1 after training on a fixed speed rotarod compared with wild-type mice
• at 2 months, mice exhibit reduced climbing compared with wild-type mice
• mice exhibit impaired motor learning only on day 1 after training on a fixed speed rotarod compared with wild-type mice
• however, mice exhibit normal performance on an accelerating rotarod and motivation to climb is normal
• from 3 to 12 months

integument
• around eyes
• hypotrichosis
• reduced density at P7

growth/size/body
• at 12 months

cellular
• in the striatum at 6 months

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:191129


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory