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Phenotypes Associated with This Genotype
Genotype
MGI:5466506
Allelic
Composition
Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic
Background
FVB.129P2-Zdhhc13Gt(AC0492)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zdhhc13Gt(AC0492)Wtsi mutation (0 available); any Zdhhc13 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• normal survival (J:191129)
• normal survival (J:191129)

nervous system
• in the striatum at 6 months (J:191129)
• in the striatum at 6 months (J:191129)
• from 3 to 12 months (J:191129)
• from 3 to 12 months (J:191129)
• reduced volume at 3 and 6 months (J:191129)
• reduced volume at 3 and 6 months (J:191129)
• reduced volume at 6 months (J:191129)
• reduced volume at 6 months (J:191129)
• progressive reduction in volume from 3 to 12 months (J:191129)
• progressive reduction in volume from 3 to 12 months (J:191129)
• reduced volume at 3 and 6 months (J:191129)
• reduced volume at 3 and 6 months (J:191129)
• progressive reduction in volume from 3 to 12 months (J:191129)
• progressive reduction in volume from 3 to 12 months (J:191129)
• reduced weight from 3 to 12 months (J:191129)
• reduced weight from 3 to 12 months (J:191129)
• in the striatum at 6 months (J:191129)
• in the striatum at 6 months (J:191129)

behavior/neurological
• mice exhibit impaired motor learning only on day 1 after training on a fixed speed rotarod compared with wild-type mice (J:191129)
• mice exhibit impaired motor learning only on day 1 after training on a fixed speed rotarod compared with wild-type mice (J:191129)
• at 2 months, mice exhibit reduced climbing compared with wild-type mice (J:191129)
• mice exhibit impaired motor learning only on day 1 after training on a fixed speed rotarod compared with wild-type mice (J:191129)
• however, mice exhibit normal performance on an accelerating rotarod and motivation to climb is normal (J:191129)
• at 2 months, mice exhibit reduced climbing compared with wild-type mice (J:191129)
• mice exhibit impaired motor learning only on day 1 after training on a fixed speed rotarod compared with wild-type mice (J:191129)
• however, mice exhibit normal performance on an accelerating rotarod and motivation to climb is normal (J:191129)
• from 3 to 12 months (J:191129)
• from 3 to 12 months (J:191129)

integument
• around eyes (J:191129)
• around eyes (J:191129)
• hypotrichosis (J:191129)
• hypotrichosis (J:191129)
• reduced density at P7 (J:191129)
• reduced density at P7 (J:191129)

growth/size/body
• at 12 months (J:191129)
• at 12 months (J:191129)

cellular
• in the striatum at 6 months (J:191129)
• in the striatum at 6 months (J:191129)

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:191129


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory