Mouse Genome Informatics
hm
    Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
FVB.129P2-Zdhhc13Gt(AC0492)Wtsi
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
N
• normal survival (J:191129)

nervous system
• in the striatum at 6 months
• from 3 to 12 months
• reduced volume at 3 and 6 months
• reduced volume at 6 months
• progressive reduction in volume from 3 to 12 months
• reduced volume at 3 and 6 months
• progressive reduction in volume from 3 to 12 months
• reduced weight from 3 to 12 months
• in the striatum at 6 months

behavior/neurological
• mice exhibit impaired motor learning only on day 1 after training on a fixed speed rotarod compared with wild-type mice
• at 2 months, mice exhibit reduced climbing compared with wild-type mice
• mice exhibit impaired motor learning only on day 1 after training on a fixed speed rotarod compared with wild-type mice
• however, mice exhibit normal performance on an accelerating rotarod and motivation to climb is normal
• from 3 to 12 months

integument
• around eyes
• hypotrichosis
• reduced density at P7

growth/size/body
• at 12 months

cellular
• in the striatum at 6 months

Mouse Models of Human Disease
OMIM IDRef(s)
Huntington Disease; HD 143100 J:191129