Phenotypes Associated with This Genotype

Genotype
MGI:5466502

• Allelic Composition: Cyp26b1^tm1Hmd/Cyp26b1^tm1Hmd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

impaired skin barrier function ( J:192725 )

• impaired skin barrier function from E16.25-E19

abnormal hair follicle development ( J:192725 )

• hair follicle growth arrested at E18.5

abnormal epidermal layer morphology ( J:192725 )

• abnormalities start to appear around E17.5

abnormal epidermis stratum basale morphology ( J:192725 )

• increased number of proliferative cells in the basal layer of the epidermis

abnormal epidermis stratum corneum morphology ( J:192725 )

• little development of the cornified layers at E17.5

• cornified layers significantly reduced at E18.5

• cornified layers are reduced and difficult to distinguish by light microscopy

• intact nuclei found under the stratum corneum

abnormal corneocyte envelope morphology ( J:192725 )

• cornified envelope is fragile and irregular in morphology at E18.5

absent keratohyalin granules ( J:192725 )

• granular layer of the skin lacks keratohyalin granules

homeostasis/metabolism

impaired skin barrier function ( J:192725 )

• impaired skin barrier function from E16.25-E19

immune system

abnormal lymphatic vessel endothelial cell morphology ( J:206581 )

• expanded distribution of PROX1+ and LYVE1 lymphatic endothelial cell progenitor (LEC) cells to the ventral and medial aspects of the cardinal vein at E11.5