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Phenotypes Associated with This Genotype
Genotype
MGI:5464285
Allelic
Composition
Muttm1Pai/Muttm1Pai
Tg(MUT)AHlps/0
Tg(MUT*R403X)#Hlps/0
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Muttm1Pai mutation (0 available); any Mut mutation (10 available)
Tg(MUT)AHlps mutation (0 available)
Tg(MUT*R403X)#Hlps mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• high methylmalonic acid in the urine, blood, liver, kidney, brain and muscle at 6 weeks
• increased C3 propionylcarnitine in the urine and blood 1 day prior to birth, at birth and at 16 hours
• high methylmalonic acid in the blood at 6 weeks, but not as much as in Muttm1Pai/Muttm1Pai Tg(MUT*R403X)#Hlps mice
• high methylmalonic acid in the urine at 6 weeks
• mice have occasional episodes of sickness (decreased movement, hunched over and ruffled fur) from which they recover within 2 hours of treatment with a liquid mixture of ground up food pellet and baby formula and placement on a heat pad
• however, feeding mice this diet during the first part of life prevents these episodes

growth/size/body
• more so in female mice
• more so in female mice

liver/biliary system
• at 2 years

renal/urinary system
• high methylmalonic acid in the urine at 6 weeks


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory