Phenotypes for Trp53 Uimc1 MGI:5463923 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Trp53^tm1Tyj/Trp53⁺ Uimc1^tm1.2Amj/Uimc1^tm1.2Amj
Genetic Background	involves: 129S2/SvPas * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
Uimc1^tm1.2Amj mutation (0 available); any Uimc1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor growth/size ( J:191827 )

• weight of ionizing radiation induced thymic lymphomas is increased compared to mutant mice wild-type for Uimc1

increased lymphoma incidence ( J:191827 )

• 78.5% of mice (11 of 14) develop thymic lymphomas after exposure to ionizing radiation

increased incidence of tumors by ionizing radiation induction ( J:191827 )

• 78.5% of mice (11 of 14) develop thymic lymphomas after exposure to ionizing radiation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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