Mouse Genome Informatics
cx
    Tg(APPSWE)2576Kha/0
Tg(PSEN1)5Dbo/0

involves: C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• dense amyloid beta plaques in the cortex and hippocampus, but not in the adrenal medulla
• amperometric recordings from chromaffin cells stimulated with a 10 second 70 mM potassium pulse indicate that the quantity of catecholamines released during the initiation of the fusion pore is 50% smaller in mutants than in controls
• chromaffin cells exhibit smaller quantal size and faster kinetics of single exocytotic events (45% lower spike half-width, 60% smaller quantal size, 50% lower decay time) and spike feet show 60% smaller quantal size
• mutants, however, exhibit normal innervation by splanchnic cholinergic nerve terminals of chromaffin cells

homeostasis/metabolism
• chromaffin cells release 50% less catecholamine (mean quantal content released per vesicle is halved) in response to a 10 second 70 mM potassium pulse
• dense amyloid beta plaques in the cortex and hippocampus, but not in the adrenal medulla

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:191088