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Phenotypes Associated with This Genotype
Genotype
MGI:5462253
Allelic
Composition
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm1Sbn/Traf3ip2+
Genetic
Background
involves: 129 * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (17 available)
Traf3ip2tm1Sbn mutation (0 available); any Traf3ip2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 7.7% of mutants are still alive at 12 months of age
• only 7.7% of mutants are still alive at 12 months of age

renal/urinary system
• infiltrating neutrophils and monocytic cells in the kidney, extending into interstitial regions

immune system
• neutrophil extracellular traps are seen in the kidneys
• increase in numbers of neutrophils and monocytic cells in perfused kidneys
• increase in CD11b+CD11c+ myeloid dendritic cells in spleens
• increase in CD11c+B220+ plasmacytoid dendritic cells in spleens
• increase in CD11b+CD11c- monocytic cells in spleens
• increase in numbers of monocytic cells in perfused kidneys
• expansion of IFN-gamma producing cells, mainly T cells, in spleens
• increase in numbers of double negative T cells in the kidneys
• increase in numbers of T effector-memory cells (CD4+CD62L-CD44+)
• increase in numbers of CD4+ T cells, and to a lesser degree, CD8+ T cells, in the kidneys
• form spontaneous germinal centers
• total serum IgG is increased and IgG deposition in the kidneys
• presence of anti-nRNP (ribonucleoprotein) antibodies
• presence of double-stranded DNA IgG antibodies
• infiltrating neutrophils and monocytic cells in the kidney, extending into interstitial regions

hematopoietic system
• neutrophil extracellular traps are seen in the kidneys
• increase in numbers of neutrophils and monocytic cells in perfused kidneys
• increase in CD11b+CD11c+ myeloid dendritic cells in spleens
• increase in CD11c+B220+ plasmacytoid dendritic cells in spleens
• increase in CD11b+CD11c- monocytic cells in spleens
• increase in numbers of monocytic cells in perfused kidneys
• expansion of IFN-gamma producing cells, mainly T cells, in spleens
• increase in numbers of double negative T cells in the kidneys
• increase in numbers of T effector-memory cells (CD4+CD62L-CD44+)
• increase in numbers of CD4+ T cells, and to a lesser degree, CD8+ T cells, in the kidneys
• form spontaneous germinal centers
• total serum IgG is increased and IgG deposition in the kidneys


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory