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Phenotypes Associated with This Genotype
Genotype
MGI:5461654
Allelic
Composition
Ube3atm1Alb/Ube3a+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ube3atm1Alb mutation (2 available); any Ube3a mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice with maternal deficiency (inheriting the null allele from the mother) exhibit increased epinephrine levels in the midbrain
• mice with maternal deficiency exhibit increased dopamine levels in the striatum and cortex
• DOPAC levels are increased in the striatum and midbrain
• mice with maternal deficiency exhibit increased 5HT (serotonin) levels in the frontal cortex and striatum

nervous system
• mice with maternal deficiency exhibit increased dopamine levels in the striatum and cortex
• DOPAC levels are increased in the striatum and midbrain

Mouse Models of Human Disease
OMIM ID Ref(s)
Angelman Syndrome; AS 105830 J:190050


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory