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Phenotypes Associated with This Genotype
Genotype
MGI:5461066
Allelic
Composition
Epm2aTg(TcraK,TcrbK)TG-BFlv/Epm2a+
Genetic
Background
involves: C57BL/6 * C57BL/10 * C57BR/cd * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epm2aTg(TcraK,TcrbK)TG-BFlv mutation (0 available); any Epm2a mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• variable T cell lymphoma first observed in the lymphoid organs (thymus, spleen and lymph nodes) then infiltrating liver, kidney, lung, pancreas, intestines and salivary glands
• however, over-expression of the disrupted gene decreases incidence and delays onset

mortality/aging
• maximum survival is 9 months
• median survival is 6 months

neoplasm
• variable T cell lymphoma first observed in the lymphoid organs (thymus, spleen and lymph nodes) then infiltrating liver, kidney, lung, pancreas, intestines and salivary glands
• however, over-expression of the disrupted gene decreases incidence and delays onset

cellular
• hypermethylation of the endogenous promoter near transgene insertion

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
lymphoma DOID:0060058 J:112696


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory