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Phenotypes Associated with This Genotype
Genotype
MGI:5448853
Allelic
Composition
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-TARDBP*)4Vle/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (6 available)
Tg(tetO-TARDBP*)4Vle mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• about 50% loss of dentate gyrus neurons at 1 month after Dox removal (J:170756)
• about 50% loss of dentate gyrus neurons at 1 month after Dox removal (J:170756)
• massive gliosis in cortical and hippocampal regions following Dox removal (J:170756)
• gliosis in the corticospinal tract, including the striatum, cerebral peduncles, medullary pyramids, and cervical spinal cord, following Dox removal (J:170756)
• massive gliosis in cortical and hippocampal regions following Dox removal (J:170756)
• gliosis in the corticospinal tract, including the striatum, cerebral peduncles, medullary pyramids, and cervical spinal cord, following Dox removal (J:170756)
• selective loss of corticospinal tract axons in cervical spinal cord associated with gliosis following Dox removal (J:170756)
• however, lower motor neuron loss is not observed (J:170756)
• selective loss of corticospinal tract axons in cervical spinal cord associated with gliosis following Dox removal (J:170756)
• however, lower motor neuron loss is not observed (J:170756)
• mutants rarely show accumulation of hyperphosphorylated, ubiquitinated cytoplasmic aggregates of TARDBP in neurons following Dox removal (around 1% of neurons showing aggregates) (J:170756)
• mutants rarely show accumulation of hyperphosphorylated, ubiquitinated cytoplasmic aggregates of TARDBP in neurons following Dox removal (around 1% of neurons showing aggregates) (J:170756)
• mutants switched to a doxycycline (dox)-free diet at 28 days of age show progressive neurodegeneration; neuron loss is particularly evident in the deep neocortical layers and in the dentate gyrus but is rarely seen in the hippocampal CA1 subfield and the olfactory bulb (J:170756)
• selective loss of corticospinal tract axons in cervical spinal cord following Dox removal (J:170756)
• mutants switched to a doxycycline (dox)-free diet at 28 days of age show progressive neurodegeneration; neuron loss is particularly evident in the deep neocortical layers and in the dentate gyrus but is rarely seen in the hippocampal CA1 subfield and the olfactory bulb (J:170756)
• selective loss of corticospinal tract axons in cervical spinal cord following Dox removal (J:170756)

behavior/neurological
• abnormal limb clasping as early as 1 week after dox removal that continues throughout life until sacrifice (J:170756)
• abnormal limb clasping as early as 1 week after dox removal that continues throughout life until sacrifice (J:170756)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory