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Phenotypes Associated with This Genotype
Genotype
MGI:5448852
Allelic
Composition
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-TARDBP)12Vle/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (7 available)
Tg(tetO-TARDBP)12Vle mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• microglial activation is seen in the cortex and hippocampus as early as 1 month after Dox removal
• 6 months following Dox removal
• 20% loss of dentate gyrus neurons at 1 month and about 75% loss by 3 months after Dox removal
• astrocytic activation is seen in the cortex and hippocampus as early as 1 month after Dox removal
• mutants switched to a doxycycline (Dox)-free diet at 28 days of age show progressive neurodegeneration, with neuron loss in the hippocampal dentate gyrus and neocortex beginning at about 1 month after Dox removal

behavior/neurological
• variable clasping behavior is seen approximately 1-3 months after Dox removal

hematopoietic system
• microglial activation is seen in the cortex and hippocampus as early as 1 month after Dox removal

immune system
• microglial activation is seen in the cortex and hippocampus as early as 1 month after Dox removal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory