Phenotypes Associated with This Genotype

Genotype
MGI:5448656

• Allelic Composition: Mir122^tm1.1Apts/Mir122^tm1.1Apts
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Progressive accumulation of lipid and reduced glycogen storage in Mir122^tm1.1Apts/Mir122^tm1.1Apts livers

liver/biliary system

liver inflammation ( J:190066 )

• accumulation of macrophages and monocytes

• however, expression of Mir122a reduces inflammation

abnormal liver morphology ( J:190066 )

• mice exhibit an increase in epithelial to mesenchymal transition in the liver compared with wild-type mice

decreased liver glycogen level ( J:190066 )

• however, expression of Mir122a increased glycogen storage

increased liver cholesterol level ( J:190066 )

increased liver triglyceride level ( J:190066 )

abnormal Ito cell morphology ( J:190066 )

• portal fibrosis due to activation of hepatic stellate cells

hepatic steatosis ( J:190066 )

• however, expression of Mir122a reduces steatosis

liver fibrosis ( J:190066 )

• portal fibrosis due to activation of hepatic stellate cells

• however, expression of Mir122a reduces fibrosis

increased hepatocellular carcinoma incidence ( J:190066 )

• more prevalent in males compared with females

• however, expression of Mir122a impaired carcinogenesis and tumor progression

homeostasis/metabolism

decreased circulating cholesterol level ( J:190066 )

decreased circulating HDL cholesterol level ( J:190066 )

decreased circulating VLDL cholesterol level ( J:190066 )

• however, expression of Mir122a restores VLDL levels

decreased circulating triglyceride level ( J:190066 )

increased circulating interleukin-6 level ( J:190066 )

• in tumor-bearing mice

increased circulating alanine transaminase level ( J:190066 )

• however, expression of Mir122a reduces ALT levels

increased circulating alkaline phosphatase level ( J:190066 )

• however, expression of Mir122a reduces AP levels

decreased liver glycogen level ( J:190066 )

• however, expression of Mir122a increased glycogen storage

increased liver cholesterol level ( J:190066 )

increased liver triglyceride level ( J:190066 )

immune system

increased macrophage cell number ( J:190066 )

• in the liver

increased monocyte cell number ( J:190066 )

• in the liver

increased circulating interleukin-6 level ( J:190066 )

• in tumor-bearing mice

liver inflammation ( J:190066 )

• accumulation of macrophages and monocytes

• however, expression of Mir122a reduces inflammation

neoplasm

increased hepatocellular carcinoma incidence ( J:190066 )

• more prevalent in males compared with females

• however, expression of Mir122a impaired carcinogenesis and tumor progression

hematopoietic system

increased macrophage cell number ( J:190066 )

• in the liver

increased monocyte cell number ( J:190066 )

• in the liver