Phenotypes Associated with This Genotype

Genotype
MGI:5448538

• Allelic Composition: Mir122^tm1.1Kgh/Mir122^tm1.1Kgh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mir122^tm1.1Kgh/Mir122^tm1.1Kgh mice develop hepatitis and fibrosis with age

homeostasis/metabolism

decreased circulating cholesterol level ( J:190067 )

• as early as 5 weeks of age

decreased circulating HDL cholesterol level ( J:190067 )

• as early as 5 weeks of age

increased circulating interleukin-6 level ( J:190067 )

♂ • in tumor-bearing male mice

abnormal circulating enzyme level ( J:190067 )

• increase in serum gamma-glutamyl transpeptidase

increased circulating alanine transaminase level ( J:190067 )

• in tumor-bearing mice

increased circulating alkaline phosphatase level ( J:190067 )

• at 5 weeks

• at 6 months

• in tumor-bearing mice

increased bile salt level ( J:190067 )

• in tumor-bearing mice

increased liver triglyceride level ( J:190067 )

liver/biliary system

increased liver triglyceride level ( J:190067 )

liver inflammation ( J:190067 )

• steatohepatitis with fibrosis

hepatic steatosis ( J:190067 )

liver fibrosis ( J:190067 )

increased hepatocellular carcinoma incidence ( J:190067 )

• 10 of 20 male mice at 11 to 15 months

• 9 of 19 female mice at 11 to 15 months

• tumor weight and grade is higher in male mice compared with female mice

neoplasm

increased hepatocellular carcinoma incidence ( J:190067 )

• 10 of 20 male mice at 11 to 15 months

• 9 of 19 female mice at 11 to 15 months

• tumor weight and grade is higher in male mice compared with female mice

increased tumor growth/size ( J:190067 )

♂ • tumor weight and grade is higher in male mice compared with female mice

immune system

increased circulating interleukin-6 level ( J:190067 )

♂ • in tumor-bearing male mice

liver inflammation ( J:190067 )

• steatohepatitis with fibrosis