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Phenotypes Associated with This Genotype
Genotype
MGI:5448405
Allelic
Composition
Tg(Col11a2-Npr2*)28Keoz/0
Genetic
Background
involves: C57BL/6
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phenotype observed in females
phenotype observed in males
N normal phenotype

Skeletal abnormalities in Tg(Col11a2-Npr2*)28Keoz/0 mice

growth/size/body
• from 8 to 18 weeks of age

skeleton
• naso-occipital length of the calvarium is increased
• long phalanges from 8 to 18 weeks of age
• at 18 weeks of age
• at 18 weeks of age
• disorganized arrangement of chondrocytes with increased number of hypertrophic chondrocytes
• wider in the femur and tibia at 8 weeks of age
• severe in adults
• spinal and tail vertebrae are longer compared to wild-type from 8 to 18 weeks of age

limbs/digits/tail
• long phalanges from 8 to 18 weeks of age
• at 18 weeks of age
• at 18 weeks of age
• from 8 to 18 weeks of age

behavior/neurological
• severe claudication (limping) in the legs in adults

craniofacial
• naso-occipital length of the calvarium is increased

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
bone development disease DOID:0080006 J:189658


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory